The NTLM authentication messages are embedded in the packets of application protocols such as SMB, HTTP, MSSQL, SMTP, IMAP. The LM and NTLM authentication protocols are "application protocol-independent". It means one can relay LM or NTLM authentication messages over a certain protocol, say HTTP, over another, say SMB. That is called cross-protocols LM/NTLM relay. It also means the relays and attacks possible depend on the application protocol the authentication messages are embedded in.